Both FGF21 and NT-pro-BNP levels presented significant positive correlation with hypertension, diabetes, severity of heart failure, coronary artery disease (CAD), peripheral artery disease, LA dimension, LVMI, E/e′ ratio, and LVEDP; negatively associated with hemoglobin level, estimated glomerular filtration rate (eGFR), and central diastolic blood pressure (DBP) (Table 3). The gene discussed is NPPB; the disease is diabetes mellitus.