The regulatory involvement of promoter methylation in the expression of several epilepsy- or seizure-related genes, including reelin, Grin2b/Nr2b (glutamate receptor, ionotropic, N-methyl-D-aspartate 2b), Gria2 (glutamate receptor, ionotropic, AMPA 2), and Bdnf (brain-derived neurotrophic factor), has been suggested8, 13, 14. The gene discussed is GRIN2B; the disease is epilepsy.