Yu et al. also demonstrated that noncanonical Wnt4 signaling could block ovariectomy-induced osteoporosis via inhibition of receptor activator of nuclear factor kB ligand-induced NF-kB signaling [56] (though we did not observe changes in NF-kB signaling upon siWNT4 in ILC-LTED; Fig. 5d and e). Here, CCL27 is linked to osteoporosis.