Similar molecular landscapes for the EGFR network are observed for each cancer type (Figure 1C, Supplementary Table S1) with RAS alterations most common in PAAD (86%), LUAD (39%), and COAD (50%) and PI3K alterations most common in LUSC (55%) and HNSCC (41%). The gene discussed is PIK3CB; the disease is head and neck squamous cell carcinoma.