However, apparent in the gene expression profiles of the panel of HNSCC cells (Figure 5C), the changes in TFAP2A gene expression and AP-2alpha “up” target genes are more strongly associated with changes in EGFR expression in HPV-negative cells (p-values of 0.002 and 0.04, respectively) than HPV-positive (p-values of 0.79 and 0.15, respectively). Here, EGFR is linked to head and neck squamous cell carcinoma.