As shown in Figure 4A, 11a-1 dose-dependently inhibits MeWo cell viability with an EC50 of 4.2 μM and a maximum inhibition of ~70%, but a structurally-related, inactive analog 10c [32] did not show any inhibition up to 20 μM, indicating that 11a-1 suppress melanoma cell viability through inhibiting SHP2. Here, PTPN11 is linked to melanoma.