In detail, the authors used ESRP1-null LS180 CRC cells (with MSI status) engineered to conditionally regulate expression of ectopic ESRP1 and identified for ESRP1 deficient cells grown in vitro a change in morphology with reduced adhesion and increased anchorage independent growth and grown in vivo as xenografts in nude mice an increase of tumor volume. This evidence concerns the gene ESRP1 and neoplasm.