In detail, the authors used ESRP1-null LS180 CRC cells (with MSI status) engineered to conditionally regulate expression of ectopic ESRP1 and identified for ESRP1 deficient cells grown in vitro a change in morphology with reduced adhesion and increased anchorage independent growth and grown in vivo as xenografts in nude mice an increase of tumor volume. The gene discussed is ESRP1; the disease is colorectal carcinoma.