ETV6 and acute lymphoblastic leukemia: Notably, GSEA analysis revealed significant enrichment of genes down regulated upon lnc-RTN4R-1 knockdown in transcripts that are highly expressed in ETV6/RUNX1-positive BCP-ALL, suggesting that lnc-RTN4R-1 indeed plays a role in the establishment of part of the ETV6/RUNX1-specific gene expression signature (Figure 5A).