RUNX1 and acute lymphoblastic leukemia: The leading edge of this analysis included AK7, PTPRK and GBA3, which are the most prominent examples of genes that are significantly down-regulated after lnc-RTN4R-1 knockdown, highly expressed in ETV6/RUNX1-positive BCP-ALL and also significantly down-regulated after fusion protein knockdown (Figure 5A–5B).