For example, the RNA-binding protein IGF2BP1, which is one of the most significantly up-regulated mRNA transcripts in ETV6/RUNX1-positive BCP-ALL and acts as a potent regulator of ETV6/RUNX1 mRNA stability [34], is located antisense of lnc-GIP-1 with an overlap at their respective first exons. This evidence concerns the gene RUNX1 and acute lymphoblastic leukemia.