CCND1 and Familial prostate cancer: This observation suggests that expression miR-17-92a cluster facilitates establishing an anti-oncogenic and anti-migratory environment in prostate cancer cells by down-regulating FGD4, LIMK1, cyclin D1 and SSH1, as overexpression and oncogenic/metastatic functions of these proteins are documented in prostate and other cancers [44, 61–63].