Taken together, these results confirmed that overexpression of miR-17-92a reduced synthesis of proteins involved in activation of RhoGTPase pathway (FGD4) [44], actin cytoskeleton reorganization (LIMK1) [45, 46] and cell cycle regulation (SSH1, cyclin D1) that are often hyper-activated or over-expressed in advanced prostate cancer [47–49]. This evidence concerns the gene LIMK1 and Familial prostate cancer.