To ascertain the absolute levels of CXCL13, CXCL8 and CXCL10 in CSF and serum of syphilis patients, quantitative ELISA assays were performed to examine the levels of these chemokines in neurosyphilis (n = 191) and non-neurosyphilis patients (n = 123). The gene discussed is CXCL8; the disease is neurosyphilis.