Thus, we assessed the efficacy of combined CSF CXCL13, CXCL10 and CXCL8 (Model 1) and combined the ratio of CSF/serum CXCL13, CXCL10 and CXCL8 (Model 2) as biomarkers for diagnosis of neurosyphilis. The gene discussed is CXCL10; the disease is neurosyphilis.