Ki-67 expression in 188Re-HYNIC-SP94-treated Huh-7 tumor tissue was lower (12.33 ± 0.02%) than that of the control group (41.33 ± 0.04%) (P = 0.001) and the 188Re treated group (30.67 ± 0.03%) (P = 0.001), suggesting that 188Re-HYNIC-SP94 could inhibit the excessive proliferation of HCC cells. This evidence concerns the gene MKI67 and neoplasm.