These data may be consistent with a previous study, showing that c-jun NH2-terminal kinase (JNK) signaling mediates the cell cycle arrest at G2/M phase in proximal tubular cells, and treatment with a JNK inhibitor, or bypassing the G2/M arrest by administration of a p53 inhibitor rescues renal fibrosis after IRI [58]. The gene discussed is MAPK8; the disease is renal fibrosis.