The mutations may also affect muscle, fat, bone, nerve, and skin tissues and lead to inherited neuromuscular disease with multiple phenotypic expressions such as Emery–Dreifuss muscular dystrophy (EDMD), limb girdle muscular dystrophy 1B (LGMD1B), Dunnigan-type familial partial lipodystrophy, a recessive axonal form of Charcot–Marie–Tooth neuropathy, and mandibuloacral dysplasia. The gene discussed is LMNA; the disease is familial partial lipodystrophy, Dunnigan type.