ITIH4 and HIV infectious disease: Usually these bNAbs arise after 2–3 y of persistent HIV infection and target more conserved areas on the HIV Env protein such as the CD4 binding site (CD4bs), V1V2 apex, gp120-gp41 interface, gp120 glycan patch, and the membrane proximal external region (MPER) of gp41.19,25,28-36