In vitro and in vivo studies have shown that dietary polyphenols may inhibit α-amylase and α-glucosidase, inhibit glucose absorption in the intestine by sodium-dependent glucose transporter 1, stimulate insulin secretion and reduce hepatic glucose output, suggesting that polyphenols could improve glucose homeostasis through potential multiple mechanisms of action and might be one dietary therapy for the prevention and management of diabetes [13]. This evidence concerns the gene INS and diabetes mellitus.