DAXX and breast cancer: Icariside II has been reported to increase the expression of Fas and the Fas-associated death domain (FADD) without changing the level of Daxx, which is also an Fas binding protein inducing apoptosis by activating the JNK pathway, and activate caspase-8 and caspase-3 in MCF-7 breast cancer cells, indicating the involvement of extrinsic apoptosis pathway [58].