Erkizan utilized surface plasmon resonance screening to identify a lead compound that could block the binding of the transcription activator vital oncogene EWS-FLI1 to its functional partner RNA helicase A. This resulted in the induction of apoptosis in Ewing’s sarcoma cells and reduced the growth of Ewing’s sarcoma orthotopic xenografts. The gene discussed is FLI1; the disease is Ewing sarcoma.