On the other hand, there are validated tests with serum biomarkers available to diagnose the stage of hepatic fibrosis (e.g., Wisteria floribunda agglutinin positive Mac-2-binding protein (WFA+-M2BP), hyaluronic acid (HA), 7S domain of type IV collagen, tissue inhibitor of metalloproteinase-1 (TIMP-1), type III procollagen N peptide (PIIIP), FIB4-index, etc.). This evidence concerns the gene TIMP1 and Hepatic fibrosis.