CASQ1 and Central core disease: In addition, based on the symptomatic similarity between malignant hyperthermia (MH) and CPVT2 and the observation of MH susceptibility in Casq1-null mice, mutations to Casq1, such as M87T and D244G, have been identified as possible causes or enablers of malignant hyperthermia and other skeletal muscle diseases, like vacuolar aggregate myopathy and central core disease [21,22,23].