In addition, we have previously reported that PYK2 expression inversely correlates with degree of malignancy of prostate cancer cells [30] and that expression of a PYK2 dead kinase mutant (PKM) in prostate epithelial EPN cell line induces cell motility, migration and a massive reorganization of cytoskeleton [31,32]. The gene discussed is PTK2B; the disease is prostate cancer.