As RSV is known to induce apoptosis mainly in cancer cells, we similarly propose that, because of the additive effect of RSV and PYK2 mutation or down-regulation, PYK2-defective prostate cancer cells may be more sensitive to RSV-induced type II cell death with respect to normal prostate cells, but further study are needed to confirm this hypothesis. This evidence concerns the gene PTK2B and Familial prostate cancer.