Curcumin and resveratrol possess multitargeting biological effects, both in vitro and in vivo, such as inhibition of Aβ aggregation, reduction of oxidative stress, promotion of cell growth, inhibition of cholinesterase activity, inhibition of brain pro-inflammatory responses, prevention of neuronal cell death, enhancement of neuroprotective sirtuin-1 activity, etc., [8,130] that make them ideal candidates in the battle against neurodegenerative diseases. The gene discussed is SIRT1; the disease is neurodegenerative disease.