Continuous EET or much earlier EET may be needed for lasting anxiolytic effects; a study has shown prenatal EET (3-week gestation and 3-week postnatal) restored deficits in emotion-related behavior caused by adulthood stress in young adult rats.71 Further understanding early-life EET and mechanisms of epigenetic BDNF regulations17, 72 across ages may be valuable to reduce anxiety as well as other psychiatric disorders.73, 74, 75. This evidence concerns the gene BDNF and psychiatric disorder.