BDNF and Anxiety: Continuous EET or much earlier EET may be needed for lasting anxiolytic effects; a study has shown prenatal EET (3-week gestation and 3-week postnatal) restored deficits in emotion-related behavior caused by adulthood stress in young adult rats.71 Further understanding early-life EET and mechanisms of epigenetic BDNF regulations17, 72 across ages may be valuable to reduce anxiety as well as other psychiatric disorders.73, 74, 75