BDNF and hyperinsulinemic hypoglycemia, familial, 4: Many studies, including ours, have shown those effects of EET in a certain period of time or in normal conditons.7, 28, 31, 32, 33, 48, 49, 50, 51 Our results indicate that early-life EET is more effective than EET during young or old adulthood in decreasing depressive behavior and restoring BDNF levels, particularly in promoter IV-BDNF deficiency.