ATG5 and Global developmental delay: One exception is that the conditional elimination of Atg7 in POMC neurons leads to a defect in postnatal axonal outgrowth (Coupe et al., 2012), and recently, a partial LoF mutation in a core autophagy gene, Atg5, have been reported to lead to cerebellar hypoplasia and developmental delay (Kim et al., 2016), but connectivity of the callosum appears unaffected.