For example, an abnormal dopaminergic commissure at the level of the diencephalon traveling through the hypothalamus from the MFB has been previously reported in the Slit1/Slit2 double KO (Bagri et al., 2002), the Deleted in colorectal cancer (Dcc) KO (Xu et al., 2010), and the NK2 Homeobox 1 (Nkx2.1) KO (Kawano et al., 2003) mice. This evidence concerns the gene SLIT1 and colorectal cancer.