In June 2010, a new class of medications known as receptor activator of nuclear factor kappa-B ligand (RANKL) inhibitors, specifically Denosumab, was approved by the FDA for treatment of osteoporosis (Prolia) and bony metastases from solid tumors such as breast and prostate cancer (Xgeva). The gene discussed is TNFSF11; the disease is osteoporosis.