Furthermore, glucose deprivation and 2DG administration may also affect sensitivity to apoptotic agents in a cell and tumor-dependent fashion.31–33 This includes sensitization to aoptosis by AMPK-mTOR control of MCL-1 and Bcl-2 family proteins, which can be either pro or anti-apoptotic depending on the cell type and inherent sensitivity to TRAIL. This evidence concerns the gene TNFSF10 and neoplasm.