Activation of the MEK/ERK pathway is a major promoter of tumor development and is responsible for the transcription of many critical miRNAs.26,27 As miRNAs have been implicated as regulators of apoptosis and TRAIL-induced cell death,28 the effect of 2DG on post-transcriptional regulation was further investigated. The gene discussed is TNFSF10; the disease is neoplasm.