Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a DR ligand that can induce apoptosis selectively in cancer cells with little-to-no effect on normal cells.8 TRAIL has been successfully utilized to suppress human tumor xenograft growth in several TRAIL-susceptible preclinical models;9–12 unfortunately, most human colon cancers are TRAIL resistant. This evidence concerns the gene TNFSF10 and cancer.