This datum is in agreement with Al–Fakhri and Abid, 200513 who, studying the effects of maintenance therapy with MTX and 6–mercaptopurine on the liver of 30 children with ALL, did not find significant changes in total serum proteins, albumin, and A/G ratio.13 In fact, the liver can increase protein and albumin biosynthesis during diseases associated with protein loss, or in the presence of liver cell damage or injury induced by cytotoxic drugs until severe parenchymal damage.7 Here, ALB is linked to acute lymphoblastic leukemia.