CST4 and kidney injury: This datum is against the report of Krawczeski et al., 2010 who found that the optimal cut-off time at post burn was the day 14 (a condition produces the same drawbacks on the kidney as the acute hemolysis do) when both serum creatinine and serum cystatin were within normal range.31 This could be explained by the flow phase (following acute stages of burn-induced kidney injury) which is characterized by hyperdynamic circulation and hypermetabolic state.