Hypotension, a known adverse effect of interferon (INF), is a known risk factor of ischemic colitis and ischemic colitis is one of the serious adverse events of treatment with IFNs type I. Ischemic colitis should be considered in INF and acetylcholine inhibitors (AChI) and calcium channel blockers (CCB) co-administration.8,9. Here, CBLIF is linked to ischemic colitis.