Of note, the increased expression of CatB mRNA in the fibroblasts was observed at 24 and 48 h but not at 3 or 12 h after challenge with P.g. LPS, which agreed with the previous finding that CatB levels were not increased in the acute and intermediate stages of bacterial infection [37], implying that Cat B expression in fibroblasts might be induced by chronic activation of TLR2 signaling. The gene discussed is TLR2; the disease is bacterial infectious disease.