IL6 and acute coronary syndrome: Al Shahi et al. carried out a study with 20 acute coronary syndrome patients and 50 stable coronary artery disease patients, and discovered that the higher plasma levels of IL-6 was associated with the pathogenesis of atherosclerosis.25 Eiras et al. reported that epicardial adipose tissue of coronary artery diseases was associated with higher levels of IL-6 mRNA than that of non-coronary artery disease patients.26 Another study was carried out in The Netherlands, and reported that plasma levels of IL-6 was significant higher in coronary artery disease compared to healthy controls.27