IL6 and osteoporosis: Since single nucleotide polymorphisms of IL-6 gene promoter may affect the expression and secretion of IL-6, and subsequently the altered circulating levels might result in relevant biological responses, the IL-6 polymorphism has been regarded as a crucial modulator in pathogenesis of various diseases, such as ischemic stroke, osteoporosis, dyslipidemia, hypertension and cardiovascular diseases.10-14