Alteplase (rt-PA) is a recombinant tissue-type plasminogen activator, by binding to fibrin, it could activate and transfer the plasminogen into plasmin, thus dissolving thrombus.7-9 rt-PA is the drug currently recommended for stroke in the AIS treatment guidelines of different countries.10-12 Because of the differences in the races, physical conditions, or other aspects among different countries, the application dose of rt-PA still needs to be further explored in clinical. This evidence concerns the gene PLG and Stroke.