Indeed, visceral (i.e., mesenteric, epididymal, and retroperitoneal) and subcutaneous WAT in cancer cachexia present increased expression of proinflammatory cytokines (i.e., TNF-α, IL-6, and IL-1β), acute phase proteins (i.e., C-reactive protein (CRP)), and chemotaxis factors (i.e., monocyte chemoattractant protein-1 (MCP-1)), concomitant to increased NF-κBp65, IKK-α, and toll-like receptor 2 (TLR2) expression [85, 105, 106, 109, 110]. Here, TNF is linked to cancer.