GNA11 and uveal melanoma: Loss-of-function Gα11 mutations give rise to FHH2 (Nesbit et al. 2013a, Gorvin et al. 2016), whereas germline gain-of-function Gα11 mutations are associated with ADH2 (Fig. 4 and Table 1) (Mannstadt et al. 2013, Nesbit et al. 2013a, Li et al. 2014, Piret et al. 2016) and somatic gain-of-function Gα11 mutations cause uveal melanomas (Van Raamsdonk et al. 2010).