Compared with mock treatment, the transcripts upregulated by TMV-P0 treatment in TRV control plants (2871 genes) but downregulated by CaLecRK-S.5 silencing in response to TMV-P0 infection (2240 genes) may be involved in CaLecRK-S.5-mediated resistance response (Fig. 7C and Supplementary Table S5). This evidence concerns the gene RPS5 and infection.