PEBP1 and colonic neoplasm: Firstly, Sam Cross-Knorr [18] reported that nuclear p-Ser153 RKIP-high expression is associated with poor prognosis whereas cytoplasmic p-Ser153 RKIP-high expression is associated with better prognosis in stage II colon cancer patients, which indicates that p-Ser153 RKIP might play a quite different role from cytoplasm to nuclei.