ADORA2A and systemic inflammatory response syndrome: Even though there were no significant differences of SIRS severity score between WT and A2AR KO at 6 hours,while the score in A2AR KO group was higher than WT group at 24 hours, the mortality in LPS treated A2AR KO was higher compared with LPS treated WT group (Fig. 1D), which indicates that A2AR is an important receptor involved in anti-SIRS.