Thus, in the present study, we investigated the effect of A2AR on neutrophil apoptosis and autophagy, and their relationship in an LPS-induced SIRS model, and deciphered the detailed molecular mechanisms in isolated murine neutrophils.We found that A2AR inhibited apoptosis of neutrophils in an autophagy-dependent manner both in vivo and in vitro. Here, ADORA2A is linked to systemic inflammatory response syndrome.