PDCD4 is widely recognized as an important tumor suppressor, as its expression is dramatically downregulated in many cancer types, including CRC (Yang et al., 2006), lung cancer (Chen et al., 2003), breast cancer (Gonzalez-Villasana et al., 2012) and gastric cancer (Guo et al., 2013). The gene discussed is PDCD4; the disease is colorectal carcinoma.