sel-10 was found as a negative modulator of LIN-12/Notch through genetic analysis in C. elegans (Sundaram and Greenwald 1993; Hubbard et al. 1997); its ortholog, Fbw7, was subsequently found to be a tumor suppressor that contributes to T-cell acute lymphoblastic leukemia (T-ALL) via negative modulation of Notch1 (Oberg et al. 2001; Wu et al. 2001; Gupta-Rossi et al. 2001). Here, NOTCH1 is linked to T-cell acute lymphoblastic leukemia.