TBX21 and arthritic joint disease: Via oral gavage, administration of BMEVs to IL-1Ra−/− mice and collagen-induced arthritis mice was shown to result in delayed onset of arthritis and diminished cartilage pathology and bone marrow inflammation; similarly, it diminished the anti-collagen IgG2a levels and was accompanied by reduced splenic Th1 (Tbet) and Th17 (RORγT) mRNA18.