Moreover, immunohistochemical analysis showed co-localization of AT1 receptor and vascular endothelial growth factor (VEGF), a major angiogenic protein, in pancreatic cancer cells [46], and expression of AT1 receptor was detected more frequently in high-grade invasive ovarian cancer than in benign ovarian tumor, and was positively correlated with expression of VEGF [42]. Here, VEGFA is linked to familial pancreatic carcinoma.