MAPT and Alzheimer disease: Classical AD neuropathology involves the accumulation of misfolded endogenous proteins, hallmarked as extracellular amyloid β-protein (Aβ) plaques, and intracellular neurofibrillary tangles (NFT), which result from the aggregation of hyperphosphorylated tau protein (pTau) [11, 66, 76, 153, 165, 166].