Current models predict either the risk of carrying a high-risk genetic mutation such as BRCA1/2 (e.g., Claus model, BOADICEA, and BRCAPRO) or the risk of developing breast cancer over time with or without such a mutation (e.g., Gail model, BOADICEA, Rosner-Colditz model, and Tyrer-Cuzick model) [5]. The gene discussed is BRCA1; the disease is breast carcinoma.