After adjusting for potential risk factors (including age, BMI, smoking, diabetes, hypertension, eGFR, education, income, MI, stroke, use of alcohol, antihypertensive medication, insulin or oral hypoglycemic agents, lipid-lower therapy, and estrogen replacement), there was a trend that multiparae with more than two children had a lower risk of hypercholesterolemia. This evidence concerns the gene INS and hypertensive disorder.