In colon cancer cells, Rack1 inhibits apoptosis by directly interacting with FEM1 homolog b (FEM1b), an intracellular pro-apoptotic protein, and thus promoting its ubiquitination and degradation, while downregulation of Rack1 led to FEM1b-mediated apoptosis8. The gene discussed is FEM1B; the disease is malignant colon neoplasm.