Horseshoe conformations are also found for the N-terminal four Ig domains of a number of other IgSF molecules including all members of the deleted in colorectal cancer (DCC), CNTN, L1, Dscam, cell adhesion associated oncogene regulated (CDON), MAM domain–containing glycosylphosphatidylinositol anchors (MDGA), and activated leukocyte cell adhesion molecule (ALCAM) families (Chen et al., 2013). This evidence concerns the gene CDON and colorectal cancer.