So we report here that AGEs mainly reduces the expression of ABCG1 but not ABCA1 in a LXRα-independent manner in THP-1 macrophages, supporting the notion that ABCG1 may be especially important in diabetic atherosclerosis and providing a novel mechanistic insight into the relationship between HDL and atherosclerosis risk in diabetic patients. The gene discussed is ABCA1; the disease is atherosclerosis.