The factors significantly associated with both shorter DSS and EFS in 112 cases of STSs were the age of the patients, tumor stage, depth of tumor, lymph node metastasis, distant metastasis, histologic grade, the number of cells undergoing mitosis, tumor necrosis, and the expression of PARP1, γH2AX, and BRCA2 (Fig 3). This evidence concerns the gene PARP1 and metastatic malignant neoplasm in the lymph nodes.