PARP1 and neoplasm: In overall STSs, the expression of PARP1, γH2AX, and BRCA2 all correlated with aggressive tumor features, including advanced tumor stage and distant metastasis, while PARP1 and γH2AX correlated with poor histologic prognosticators, including higher histologic grade and increased mitotic count, as well as with expression of other DDR molecules (Table 2).