MGMT and colorectal carcinoma: In a large cohort study with 1123 CRC, a strong association with MGMT methylation was found with KRAS mutations both in univariate analysis (OR 2.3, 95% CI 1.7–3.0, P < 0.0001) and multivariate analysis (OR 1.9, 95% CI 1.5–2.6, P < 0.0001).