As homogenous/speckled pattern reflects the development of anti-DNA or anti-extractable nuclear antigen (ENA) Abs, we measured anti-ENA Abs including lupus-specific autoantibodies, such as anti-Sm and anti-U1-RNP Abs; however, none of the patients developed these lupus-specific anti-ENA Abs as well as lupus manifestations during the observation periods. Here, SNRNP70 is linked to systemic lupus erythematosus.