Abnormal RyR2 gating mechanism may arise from increased phosphorylation by protein kinase A (PKA, serine 2808) and Ca2+/calmodulin-dependent protein kinase II (CaMKII, serine 2808 and serine 2814) [55–57], as well as oxidation by ROS and reactive carbonyl species (RCS), which are increased in diabetes [58–60]. Here, RYR2 is linked to diabetes mellitus.