PPARA and metabolic dysfunction-associated steatotic liver disease: In recent years, the supplement of n-3 PUFAs, such as fish oil rich in EPA and DHA, has been recommended for the prevention and treatment of NAFLD; its inner mechanisms included increasing hepatocellular fatty acid oxidation by activating the peroxisome proliferator activated receptor α (PPAR-α), inhibiting de novo fatty acid synthesis via regulating the expression and maturity of sterol regulatory element-binding protein-1c (SREBP-1c) [22].