Nonalcoholic fatty liver disease (NAFLD) is an acquired metabolic stress-induced liver injury, except alcohol and other established impairing liver factors, caused by excessive deposition of fat in the hepatocytes as the main feature of the clinical syndrome, and closely related to genetic susceptibility to insulin resistance, its histological spectrum encompasses simple steatosis (SS); steatosis with necroinflammation, which known as nonalcoholic steatohepatitis (NASH); and cirrhosis [1–5]. The gene discussed is INS; the disease is metabolic dysfunction-associated steatohepatitis.